Brown Institute for Brain Science

Cylinder Test

Rationale of Test

The Cylinder test is designed to evaluate locomotor asymmetry in rodent models of CNS disorders. This test is used to phenotype strains of transgenic mice and evaluate novel chemical entities for their effect on motor performance.

Apparatus

Procedure

The animal is placed in an open top clear plastic cylinder. As the animal moves within the cylinder, its forelimb activity while rearing against the wall of the arena is recorded. Forelimb use is defined by the placement of the whole palm on the wall of the arena, which indicates its use for body support. Forelimb contacts while rearing are scored with a total of 20 contacts recorded for each animal. The number of impaired and unimpaired rears will be recorded.

Interpretation

Relevant Controls

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