Brown Institute for Brain Science

Mid-air Righting Reflex

Rationale of Test

This task is used to assess early development of motor coordination and orientation of self in space. Mice are oriented int he prone position and dropped from a short distance above a surface. This task assessed the animals ability to right itself while falling in order to land on its feet.

Apparatus

Padded surface, ruler, high speed video camera.

Procedure

Mice are raised 16" above a padded surface, oriented in the prone position (back facing the ground) and dropped. Behavior is recorded during the drop and analyzed off-line. This is repeated 5 times and average latency to right, or percent success in righting are recorded from high speed video.

Interpretation

Failures or delays in the ability to right can be indicative of impairments in motor coordination or vestibular dysfunction.

Relevant Controls

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