Brown Institute for Brain Science

Righting Reflex

Rationale of Test

This task is commonly used to assess basic motor coordination of mice at early developmental ages. It assessed the ability of the mouse to coordinate the necessary movement to roll over from it's back onto it's paws. Inability to right, or significant delays in righting can indicate delays or impairments in motor development or motor functioning.

Apparatus

Video Camera, flat surface.

Procedure

From postnatal day 4 to postnatal day 11, mice are placed flat on their back on an flat surface and then released. During the trial the mouse is recorded and the latency to right itself (4 paws on the ground) is assessed. This is repeated 5 times per day and the average time to right or maximum time to right are collected.

Interpretation

Delays in the ability to right, or significantly longer latencies to right compared with a relevant control are indicative of motor impairments or motor delays.

Relevant Controls

none

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